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Dancing liquid - vibration eigenmode shapes of liquids
Urban, Ondřej ; Pochylý, František (referee) ; Rudolf, Pavel (advisor)
This bachelor's thesis deals with phenomena connected with vertically oscillating liquid layer, particularly with Faraday waves and liquid atomization. More in detail it deals with the linear mathematical model for vertically oscilating inviscid and incompresible liquids by Benjamin & Ursell (1954). It also presents the appearance of these and other phenomena connected with liquid vibration in practical applications. Furthermore, results of experiments are presented. Their aim was to find some eigenmode shapes using the linear model and also to document some of their properties. Final part is aimed to the design of an experimental device for visualization of vibration eigenmode shapes of liquids.
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Inhalers and nebulizers for treatment of diseases caused by bacteria
Kánská, Jana ; Bělka, Miloslav (referee) ; Lízal, František (advisor)
One of today's problems that threaten the future of humanity is the ever-increasing bacterial resistance to antibiotics. It is therefore necessary to look for new treatments against bacterial diseases. A possible alternative to antibiotics is treatment with bacteriophages. This work aims to help to increase the effectiveness of bacteriophage treatment. The first part of the thesis contains a survey of inhalation devices and focuses in particular on the devices most suitable for phage therapy, i.e. treatment with bacteriophages. Furthermore, there is a brief overview of phage therapy and the studies already conducted on this topic. In the experimental section, three experiments are described. In the first two experiments, the model drugs were liposomes. First, their size distributions were measured after nebulization using two types of nebulizers (jet and mesh). Next, the deposition of liposomes after nebulization was monitored in a simplified lung model. In the third experiment, phage lysates were nebulized using three different nebulizers (two jet and one mesh). The nebulized lysates were captured in a sterile tube so that the stability of the phages after nebulization could be subsequently evaluated. The experimental part showed that during liposome nebulization, the jet nebulizer produced more FPF than the mesh nebulizer. It was further found that during nebulization with the jet nebulizer, almost the same amount of aerosol entered the lungs as remained in the mouthpiece, with a large amount also remaining in the nebulizer itself. A third experiment showed that neither nebulizer substantially degraded the phage lysate.
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Inhalers and nebulizers for treatment of diseases caused by bacteria
Kánská, Jana ; Bělka, Miloslav (referee) ; Lízal, František (advisor)
One of today's problems that threaten the future of humanity is the ever-increasing bacterial resistance to antibiotics. It is therefore necessary to look for new treatments against bacterial diseases. A possible alternative to antibiotics is treatment with bacteriophages. This work aims to help to increase the effectiveness of bacteriophage treatment. The first part of the thesis contains a survey of inhalation devices and focuses in particular on the devices most suitable for phage therapy, i.e. treatment with bacteriophages. Furthermore, there is a brief overview of phage therapy and the studies already conducted on this topic. In the experimental section, three experiments are described. In the first two experiments, the model drugs were liposomes. First, their size distributions were measured after nebulization using two types of nebulizers (jet and mesh). Next, the deposition of liposomes after nebulization was monitored in a simplified lung model. In the third experiment, phage lysates were nebulized using three different nebulizers (two jet and one mesh). The nebulized lysates were captured in a sterile tube so that the stability of the phages after nebulization could be subsequently evaluated. The experimental part showed that during liposome nebulization, the jet nebulizer produced more FPF than the mesh nebulizer. It was further found that during nebulization with the jet nebulizer, almost the same amount of aerosol entered the lungs as remained in the mouthpiece, with a large amount also remaining in the nebulizer itself. A third experiment showed that neither nebulizer substantially degraded the phage lysate.
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|
Dancing liquid - vibration eigenmode shapes of liquids
Urban, Ondřej ; Pochylý, František (referee) ; Rudolf, Pavel (advisor)
This bachelor's thesis deals with phenomena connected with vertically oscillating liquid layer, particularly with Faraday waves and liquid atomization. More in detail it deals with the linear mathematical model for vertically oscilating inviscid and incompresible liquids by Benjamin & Ursell (1954). It also presents the appearance of these and other phenomena connected with liquid vibration in practical applications. Furthermore, results of experiments are presented. Their aim was to find some eigenmode shapes using the linear model and also to document some of their properties. Final part is aimed to the design of an experimental device for visualization of vibration eigenmode shapes of liquids.
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